ODBORNOSTI

PGT-A

Pre-implementation genetic testing is intended for the diagnosis of chromosomal aberrations or homogeneously inherited diseases of the embryo before its implantation into the uterus of the future mother. The aim of testing is to reduce the risk of miscarriages, increase the likelihood of pregnancy and clarify the causes of IVF failure. Material for genetic testing of embryos is most often obtained from embryos at the blastocyst stage (ie the 5th or 6th day of embryonic development). Embryos intended for genetic testing are cultured in timelapse monitoring, through the biopsy itself it is necessary to open the embryo envelope (by the method of assisted hatching) and then the cells are removed for testing using a thin glass needle. Embryos are frozen after collection. Transfer is possible only after receiving the biopsy results. PGT-A Pre-implementation genetic testing of aneuploidies diagnoses genomic mutations, numerical chromosomal defects. PGT-A is recommended for elderly patients with previous recurrent miscarriages, repeated failed IVF attempts, or couples with abnormal spermiograms. PGT- SR Pre-implementation genetic testing for structural chromosome defects detects unbalanced chromosome rearrangements of the embryo. PGT-SR is recommended if one of the pair carries a balanced chromosomal rearrangement. PGT- M Pre-implementation genetic testing for monogenic diseases is always indicated by a physician-geneticist and diagnoses gene mutations.

 

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